00:00 The podcast episode discusses the latest science on CBD, THC, and cannabis, exploring their differences, effects on the body, safety issues, and the evolving landscape surrounding these compounds.

06:44 The podcast guests discuss their personal motivations for studying cannabis as a medicinal molecule and the historical background of cannabis as a medicine dating back over 5000 years.

14:35 Cannabis has been used medicinally for over 5,000 years, with different methods of application and varying effects, but most people associate it with THC and intoxication.

22:11 CBD works either indirectly activating the endocannabinoid system or on different receptors than THC, and can be found in varying concentrations in different plant strains, while the Farm Bill in the U.S. has made it legal for farmers to grow hemp with less than 0.3% THC for various industrial and medicinal uses.

30:06 CBD is federally legal and regulated by states, with the Farm Bill legalizing hemp but not directly approving CBD in products, leading to ongoing FDA discussions on its safety and effectiveness.

38:41 Cannabinoids do not activate the same receptors as opioids, making it less toxic from a cardiorespiratory standpoint and having a wide therapeutic index compared to other substances like alcohol or acetaminophen.

46:43 Legalization of cannabis in states like Colorado and Washington has not shown an increase in cannabis use among young people or a gateway effect to more harmful substances, with some evidence suggesting a reduction in opioid prescriptions in states with medical cannabis programs.

54:35 Inhalation methods of cannabis administration raise concerns about cellular changes and potential health risks, with different dosing challenges compared to other methods.

01:02:43 The lack of FDA oversight in the cannabis industry due to federal illegality raises concerns about product safety and efficacy.

01:10:32 Edible cannabis products require time and temperature to extract the active ingredient THC, making it difficult to ensure consistent dosages due to individual variations in digestion and metabolism.

01:17:39 Using small amounts of cannabinoids can activate cellular processes without causing intoxication, providing relief for patients seeking pain management and anxiety reduction without the psychoactive effects of THC.

01:25:26 CBD, taken in a water-soluble form, has demonstrated effectiveness in promoting sleep, reducing anxiety, and activating GABA receptors, with potential for further research despite current legal restrictions.

01:33:46 Sublingual tablets allow for rapid systemic absorption of CBD and THC, providing quick onset of medical effects such as sleep, pain relief, and anxiety reduction.

01:49:47 The company focuses on creating products within medical and legal rules in Michigan, holding themselves to high standards despite the expensive and time-consuming process of FDA approval for new drugs.

01:57:54 The CBD and THC industry is rapidly evolving, with FDA involvement and increasing state acceptance, but concerns remain about product safety and the need for standardized testing protocols.

02:05:28 Laboratories are now capable of conducting accurate and precise testing on cannabinoid products, but state rules on product safety and testing protocols vary, highlighting the need for consumers to request certificates of analysis and educate themselves on the products they are using.