Prompt Cast
Impact of mTOR Inhibition on Cancer Treatment
TLDR Rapamycin's effectiveness in cancer treatment varies depending on the type of cancer, potentially due to cancer cells evolving to ignore signals that rapamycin targets, while its impact on the immune system could have both beneficial and detrimental effects on cancer progression. Female mice may be more sensitive to rapamycin, showing a greater mTOR inhibitory effect compared to males, leading to potential differences in lifespan benefits at lower doses of the drug.
Timestamped Summary
00:00
The podcast episode discusses the potential impact of inhibiting mTOR in cancer treatment.
01:31
Rapamycin's effectiveness in cancer treatment varies depending on the type of cancer, potentially due to cancer cells evolving to ignore signals that rapamycin targets, while its impact on the immune system could have both beneficial and detrimental effects on cancer progression.
03:10
High doses of rapamycin given to mice in a study showed different effects in male and female mice, with male mice living longer, having better muscle function, and less cancer, while female mice did not experience a difference in lifespan but developed aggressive hematopoietic cancers.
04:41
Female mice may be more sensitive to rapamycin, showing a greater mTOR inhibitory effect compared to males, leading to potential differences in lifespan benefits at lower doses of the drug.
06:06
Rapamycin may have impacted the immune system in a way that allowed immune cancers to escape surveillance or become hyperproliferative in animal studies.
07:27
Rapamycin's potential role in enhancing cancer immune therapies, particularly in the elderly, is worth considering due to its ability to potentially improve the effectiveness of such treatments.
09:02
A properly functioning immune system may help clear mutation accumulation before it becomes problematic.
Categories:
Health & Fitness
