Prompt Cast
The Peter Attia Drive: Exploring the Benefits of NAD Supplementation
TLDR NAD supplementation, particularly with precursors like nicotinamide riboside, shows potential in improving health span, especially in organs like muscle and brain, with some evidence from animal and pilot clinical studies. NAD levels can be increased through fasting, leading to skepticism about the effectiveness of NAD supplementation in affecting mitochondrial function.
Timestamped Summary
00:00
Qualies podcast features short episodes highlighting the best questions, topics, and tactics discussed on previous episodes of The Peter Attia Drive.
01:15
Supplements like NR or NAD claim to enhance longevity by addressing the decrease in the NAD to NADH ratio that occurs with aging, impacting mitochondrial function and energy production.
02:31
NAD plays a crucial role in regulating histone deacetylases and DNA repair enzymes like PARP, impacting health span and DNA damage repair.
03:46
NAD levels decline with age due to increased consumption for DNA repair and immune system activation, potentially impacted by pathways like the salvage pathway and influenced by medications like metformin.
05:02
NAD supplementation, particularly with precursors like nicotinamide riboside, shows potential in improving health span, especially in organs like muscle and brain, with some evidence from animal and pilot clinical studies.
06:14
NAD levels can be increased through fasting, leading to skepticism about the effectiveness of NAD supplementation in affecting mitochondrial function.
07:28
NAD levels can be increased through fasting, leading to skepticism about the effectiveness of NAD supplementation in affecting mitochondrial function.
Categories:
Health & Fitness
