The Truth About Resveratrol and NAD Supplements for Longevity

TLDR Recent evidence suggests that resveratrol does not increase lifespan, but grape seed extract can improve vascular function. While NAD supplements like NR and NMN may not increase lifespan, they can provide sustained mental and physical energy throughout the day. It is important to prioritize foundational factors such as sleep, exercise, and nutrition before considering supplementation for longevity.

Timestamped Summary

00:00 Resveratrol and other supplements like grapeseed extracts were once believed to potentially extend lifespan, but recent evidence suggests that there is very little, if any, direct evidence to support this claim.
03:31 Resveratrol does not increase lifespan, but grape seed extract has other health benefits such as improving vascular function and blood flow.
07:02 Increasing NAD levels through supplements like NR and NMN may not increase lifespan, but it can provide sustained mental and physical energy throughout the day.
10:41 Taking NR and NMN in the morning provides sustained energy throughout the day, but there is no expectation that it will increase lifespan, while NAD infusions can be uncomfortable and require anti-nausea medication.
14:12 NAD infusions can improve sleep, vigor, and overall well-being, but there is no clinical trial exploring their effectiveness for increasing lifespan, and they can be uncomfortable and expensive.
17:36 There is no direct evidence linking oral NAD supplements to NAD levels in cells, and it is important to prioritize foundational factors such as light exposure, movement, nutrition, and stress modulation before considering supplementation for mental and physical health and performance.
20:57 The host does not take metformin or rapamycin to increase lifespan due to insufficient data supporting their effectiveness, but instead focuses on supplements like grape seed extract, NR, NMN, and occasional NAD infusions, while emphasizing the importance of quality sleep for a long and healthy life.
24:27 There is no supplement or drug that comes close to the health benefits of quality sleep and exercise for increasing longevity, and it is important to prioritize sleep, exercise, nutrition, social connection, stress modulation, and morning sunlight before considering any supplements or drugs.

The Truth About Resveratrol and NAD Supplements for Longevity

AMA #12: Thoughts on Longevity Supplements (Resveratrol, NR, NMN, Etc.) & How to Improve Memory
by Huberman Lab

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