00:00 The podcast hosts discuss their excitement for the 1,000th episode and their love for The Simpsons.

05:38 The first episode of The Simpsons, titled "Simpsons roasting on an open fire," was actually the eighth episode to be made and featured crude animation and voice acting, and did not include the iconic opening sequence.

10:05 The Simpsons was a revolutionary primetime animated series that followed the conventions of a traditional family sitcom, but with the added twist of being animated, which hadn't been done since the 1970s, and it quickly became a huge hit and leveled the TV industry.

14:56 The Simpsons was initially compared to other family sitcoms, but it quickly became clear that it was actually subversive satire and a cultural revolution in the TV industry.

19:51 The earliest clips of The Simpsons were animated by a different studio called Claskey, Suppo, or Kupo, and despite being rough and hard to watch, they gave The Simpsons their iconic yellow skin and Marge's blue hair, which caught people's attention while channel surfing.

24:28 The cast of The Simpsons consists of six main voice actors, including Julie Kavanaugh who voices Marge and her sisters, and Yardley Smith who voices Lisa, while Dan Castellanetta voices Homer and several other characters, Nancy Cartwright voices Bart and other prepubescent characters, and Hank Azaria voices Apu and various other characters, with Apu's portrayal being the subject of controversy and criticism.

29:30 The Simpsons introduced viewers to various cultural references and encouraged them to explore movies, books, and other aspects of the world that they may not have been aware of before.

34:38 The Simpsons paid tribute to Edna Krabappel's voice actress, Marcia Wallace, in an episode and also explored themes of death and grief while maintaining the show's signature humor.

39:46 The Simpsons had a crossover episode with The Critic, which upset Matt Groening and led him to remove his name from the opening credits.

44:46 The writing process for an episode of The Simpsons involves multiple rounds of rewrites and editing, and the table read for an episode is a public event where the cast and writing staff read through the script, with some voice actors calling in on the phone.

49:31 The hosts of the podcast describe their experience meeting Matt Groening, the creator of The Simpsons, during a table read and how he was surprisingly friendly and nice, signing their scripts and drawing Bart and Homer on them.