Prompt Cast
Understanding the Impact of Rapamycin on Aging and Longevity
TLDR Rapamycin, a drug originally discovered as an organ transplant immunosuppressant, has shown promising effects on health span and longevity in animal studies. Research suggests that rapamycin may have potential benefits in reducing amyloid levels, rejuvenating the immune system, improving vaccine response, and even impacting conditions like depression and anxiety.
Timestamped Summary
00:00
The podcast discusses the discovery of rapamycin, how mTOR works, pathways of rapamycin, studies on its impact on lifespan, and the potential dosing in humans.
08:52
Rapamycin positively impacts various aspects of health span in complex animals, with ongoing veterinary clinical trials showing promising safety and potential efficacy in aging processes.
16:43
Rapamycin's clinical path as an organ transplant immunosuppressant may have negatively impacted its development for other uses, leading to a delayed understanding of its side effects and potential benefits in patients not immunocompromised.
25:12
Conserved biological processes impacting aging are fundamental and should be the focus of longevity research, with the potential for interventions like rapamycin to extend lifespan even when started in middle age.
33:25
Rapamycin dosing regimens in mice differ from potential human dosing strategies, with challenges in funding studies on different mTOR inhibitors and their effects.
42:05
Regulation of mTOR levels is not the critical factor, but rather the upstream regulation that fine-tunes the pathway in different cells, with mTORC1 being considered critical for the health of almost every cell.
50:50
The mechanisms by which mTOR inhibition and rapamycin impact the biology of aging are not fully understood, with incomplete models and uncertainties regarding the specific benefits and side effects of mTORC1 and mTORC2 inhibition.
59:06
Leucine plays a crucial role in muscle mass and satiety, with its receptor cestrin being a key player in detecting and interacting with leucine, shedding light on the complexities of mTOR activation and its impact on muscle preservation and longevity.
01:07:42
The tissue specificity of rapamycin and its potential impact on different organs remains complex and not fully understood, with questions surrounding mTOR blockade uniformity and brain penetration at varying doses.
01:15:49
Rapamycin may have potential benefits in reducing amyloid levels in high-risk patients, possibly impacting the brain through effects on the peripheral immune system and metabolic signaling, suggesting a broader need for clinical research in the field of Alzheimer's disease.
01:23:57
Rapamycin showed potential in rejuvenating the immune system in older adults, leading to increased response to vaccines and suggesting the possibility of lower doses being well tolerated as a potential gerotherapeutic.
01:32:00
The immune system's complexity and the lack of clear evidence on Rapamycin's impact as an immunosuppressant raise questions about its potential effects on biological aging and epigenetic changes.
01:40:03
Rapamycin may potentially rejuvenate immune function and protect against infections, with minimal reported side effects aside from mouth sores in users.
01:48:00
Rapamycin may have potential beneficial effects on depression and anxiety, with ongoing research exploring its combination with ketamine for conditions like depression and chronic pain.
01:56:09
Researchers are interested in exploring the potential of using rapamycin or other mTOR modulators to achieve metabolic states that cannot be reached through dietary interventions.
02:04:31
Rapamycin derivatives and mTOR inhibitors like RTB 101 have shown potential in boosting vaccine response and reducing subsequent infections, with RTB-101 alone demonstrating a signal in clinical trials.
02:13:07
mTOR impacts aging by regulating multiple processes, making it essential to address various aspects of cellular dysfunction to combat aging effectively.
02:21:21
Rapamycin studies in dogs and non-human primates show potential positive effects on longevity and health span, with dosing considerations being an important factor in study design.
02:29:24
Rapamycin dosing in humans may be lower than optimal due to risk aversion, with concerns about achieving statistically significant effects.
02:37:31
Rapamycin treatment can impact male and female reproductive systems differently due to the drug's effects on rapidly proliferating cells, with potential for rejuvenation in female mice and negative impacts on male fertility.
02:45:34
The discussion touches on various fundamental questions in biology, such as why different organisms age at different rates and why organisms of similar size have different lifespans, with plans to continue the conversation in the future.
Categories:
Health & Fitness
