00:00 There are people who cannot feel pain, a condition known as congenital insensitivity to pain with anhydrosis (SEPA), with only 60 reported cases worldwide since 1983.

04:12 Congenital insensitivity to pain with anhydrosis (SEPA) is a condition where individuals have no sensitivity to pain, heat, cold, or temperature on their skin, and it is caused by specialized nerve endings called nociceptors that are responsible for sending pain signals.

07:49 Congenital insensitivity to pain with anhydrosis (SEPA) is a condition where individuals have no sensitivity to pain or temperature, and it can lead to overheating and death in babies, as well as untreated infections and mental retardation in older patients.

11:40 SIPA, or congenital insensitivity to pain with anhydrosis, was first described in 1847 and was initially thought to be a psychological disturbance, but it is now believed to be a genetic condition possibly caused by a mutation in the TRK1 gene.

15:37 Congenital insensitivity to pain with anhydrosis (SIPA) can be difficult to diagnose in babies, as one of the first signs is witnessing an accident that should cause the baby to cry, but they don't cry due to their inability to feel pain, which can lead to serious health problems such as infections, overheating, and brain damage.

19:10 People with congenital insensitivity to pain with anhydrosis (SIPA) can suffer from constipation, fractures, and Charcot joints due to their inability to feel discomfort or pain, and it is recommended that they receive occupational therapy, baby-proof their homes, and move to cooler climates to prevent overheating.

22:51 There is currently no cure for congenital insensitivity to pain with anhydrosis (SIPA), but stem cells may hold promise for future treatments, and there are websites and a documentary available for those interested in learning more about the condition.

26:36 A listener in Chile found comfort and a sense of normalcy during a devastating earthquake and tsunami by listening to a podcast episode from "Stuff You Should Know."

30:06 The hosts make some corrections and provide contact information for listeners to send in corrections or engage in email combat.