Prompt Cast
Understanding Alzheimer's Disease Risk Factors and Prevention Strategies
TLDR The episode delves into Alzheimer's disease risk factors, the significance of knowing one's ApoE gene, and strategies for preventing Alzheimer's disease and neurodegeneration, emphasizing the importance of healthy lifestyle factors in maintaining brain health.
Timestamped Summary
00:00
The episode discusses Alzheimer's disease risk factors, the importance of knowing one's ApoE gene, and strategies for preventing Alzheimer's disease and neurodegeneration.
03:37
The episode focuses on Alzheimer's disease, neurodegeneration, and the importance of understanding the diagnosis process.
07:02
Alzheimer's disease diagnosis is complex and often requires biomarkers like serum amyloid and tau, with newer tests like the C2N developed amyloid score showing promise in predicting AD pathology based on factors like ApoE status, AB40 to 42 ratio, and age.
10:53
Amyloid PET scans are not used clinically, and the C2N test is reserved for high-risk patients due to the need for high pretest probability to enhance its predictive value for Alzheimer's disease.
14:32
Most Alzheimer's disease patients do not have deterministic genes, but about two thirds have at least one copy of the ApoE4 gene, which is highly associated with the disease but not deterministic.
18:48
Genes associated with Alzheimer's disease can be combined in various ways, with the most common being 3-3, followed by 3-4, highlighting the complexity and challenges in genetic testing beyond ApoE4.
22:38
The risk of developing all dementias, including Alzheimer's, increases with age, with certain genotypes like 4-4 showing higher risk, and women being about 20% more likely to develop Alzheimer's in a given decade compared to men.
26:58
Healthy lifestyle factors, such as not smoking, good sleep, exercise, and nutrition, can offset the risk of cognitive decline associated with the APOE E4 genotype, emphasizing the importance of these behaviors in brain health.
31:05
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