00:00 Some centenarians can lead unhealthy lives and still live a long time, like Madame Jean Clemente who smoked until she was 100 and lived to be 122.

03:32 Some centenarians can lead unhealthy lives and still live a long time, like Madame Jean Clemente who smoked until she was 100 and lived to be 122.

07:05 Research has shown that a caloric restricted diet can lead to longer and healthier lives, and one gene that has been studied in relation to longevity is the SIRT one gene, which inhibits the expression of a protein called BACs and grants cells a stay of execution, preventing cellular death and ultimately leading to longer life.

10:38 Reduced calorie diets activate the SIRT one gene, but there are likely many other genes involved in longevity, such as the FOXO3A gene, which has been shown to increase the lifespan of worms and is also found in elderly Japanese and Germans, and the IGF-1 gene, which has a mutation in a population of Ashkenazi Jews and may contribute to smaller stature and a lower risk of cancer.

14:05 Women may have longevity genes that allow them to reproduce for a longer period of time, increasing their chances of survival and passing on their genetic line.

17:35 The podcast discusses the possibility that women have a longevity gene, but it is still unclear and likely a combination of genes working together.

21:35 Old Tom Parr, who lived to be 152 years old, died after being fed food he had never eaten before at a party thrown by King Charles.

25:17 The hosts discuss their audio book and blog, and then read a listener mail about the importance of junk mail for the postal service.