The History and Uses of Nitrous Oxide: From Pain-Free Dentistry to Recreational Use

TLDR This podcast episode explores the fascinating history and various uses of nitrous oxide, from its early use in pain-free dentistry to its recreational use as "hippie crack" in the 70s. However, it is important to note that nitrous oxide can be dangerous and potentially lead to brain damage and death if used in high concentrations or for prolonged periods of time.

Timestamped Summary

00:00 This podcast episode is about the history and uses of Nitrous Oxide, also known as "Hippie Crack" or "Jazz Juice".
05:20 William Morton, the dentist who first used nitrous oxide for pain-free dentistry, performed successful dental procedures on dozens of patients but faced a disastrous demonstration at Harvard medical school, leading to his downfall and eventual death.
10:11 In 1864, William Morton was recognized by the ADA as a pioneer of using nitrous oxide in dentistry, thanks to the successful demonstrations of Gardner Colton.
15:21 Humphrey Davy conducted his first major experiment with nitrous oxide on Boxing Day of 1799, inhaling 20 quarts of the gas in a sealed box for an hour and 15 minutes, experiencing intense sensations and a heightened perception of the world around him.
20:35 Humphrey Davy experimented with nitrous oxide and found that people couldn't accurately describe their experiences with English words, leading him to write a scientific treatise on the gas and its effects on humans and animals.
25:47 Nitrous oxide is an analgesic, an anesthetic (although not a true one), and an angziolidic, meaning it diminishes anxiety by triggering the same response in the brain as benzodiazepines, and it also has the ability to cut down on pain by activating opioids and interfering with the spinal column's ability to process pain.
30:56 Nitrous oxide is known for its recreational use at concerts and festivals, where it was commonly referred to as "hippie crack" in the 70s.
35:50 Nitrous oxide has a short-lived high because it is not metabolized by the body and is expelled through breathing, which is why it was popular among hippies in the 70s.
40:47 Nitrous oxide can cause brain damage and death, especially when used in high concentrations or for prolonged periods of time.
45:47 Nitrous oxide is not only dangerous because it can cause brain damage and death, but it can also lead to accidents and poor decision-making due to the user's altered state of mind.
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