The History and Modern Use of Peyote: From Ancient Hallucinogen to Native American Ritual

TLDR Peyote, a spineless cactus native to Mexico and the Southern U.S., contains the hallucinogenic alkaloid mescaline and has a long history of use. From its potential as a treatment for schizophrenia to its role in Native American rituals, peyote has had a complex journey and continues to be used today.

Timestamped Summary

00:00 Peyote is one of the oldest hallucinogens and is a spineless cactus that contains the alkaloid mescaline, which produces hallucinogenic effects when consumed by humans.
04:20 Peyote is a spineless cactus native to Mexico and the Southern U.S. that contains the hallucinogenic alkaloid mescaline and has a reputation for being difficult to find.
08:40 Mescaline, isolated from peyote, was studied in the thirties and forties as a potential treatment for schizophrenia, but it was found to be too unreliable and individuals with schizophrenia could differentiate between their delusions and those induced by mescaline.
12:53 Mescaline, the primary psychedelic chemical found in peyote, was synthesized in 1919 by Austrian chemist Ernst Spith and later turned into a pharmaceutical by Merck, leading to further study and research on its effects.
17:37 Peyote trips typically involve nausea and vomiting before the effects set in, and the trip itself can last up to 12 hours, with intense visuals and bodily sensations.
22:18 Peyote use was widespread in North America until it was outlawed by European governments, but it has since rebounded and is now more widespread than it was a thousand years ago, partly due to American tourists and the influence of Carlos Castaneda's books.
27:01 Carlos Castaneda was exposed as a fraud who made up his anthropological field work and created a character based on his own peyote trips, despite selling millions of books.
31:08 The Native American church takes peyote, even though many tribes within the church were not traditionally exposed to it, as it was a byproduct of forced relocation and reservation settlements by the American government.
36:16 The Native American church conducted peyote rituals in secret inside TPs to avoid detection and eradication of their culture, and modern ceremonies are focused on healing and led by a road man, with participants having intense experiences and being taught by the peyote.
40:42 Mescaline and LSD have different effects due to the different ways they are synthesized and consumed, with LSD being synthesized into a small piece of paper and peyote being consumed as buttons.
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