The History and Effects of Nitrous Oxide

TLDR Nitrous oxide, also known as "hippie crack," has a long history dating back to the 1770s, with figures like Dr. Horace Wells and Humphrey Davy playing significant roles in its discovery and experimentation. While it can be used as a recreational drug, it also has medical applications as an anxiolytic, analgesic, and dissociative anesthetic, although it can be dangerous and potentially deadly when used in high concentrations or for prolonged periods of time.

Timestamped Summary

00:00 This section of the podcast is an introduction to the topic of nitrous oxide and its history, including the story of Dr. Horace Wells, a dentist in the 1830s who used nitrous oxide to alleviate pain in his patients.
05:14 Dr. Horace Wells, a dentist in the 1830s, discovered pain-free dentistry using nitrous oxide, but his attempt to demonstrate it to Harvard medical students ended in failure and he spiraled into addiction and depression.
10:16 Joseph Priestley, an Englishman and contemporary of Ben Franklin, was a polymath who studied gases in the 1770s and isolated eight different gases for the first time using a device called the pneumatic trough.
15:48 Humphrey Davy conducted an experiment on himself on December 26th, 1799, where he inhaled 20 quarts of nitrous oxide every five minutes for an hour and 15 minutes, experiencing intense sensations and a heightened perception of the world around him.
21:13 Humphrey Davy conducted experiments with nitrous oxide on himself and others, finding that the effects of the gas were difficult to describe in English words, leading to the realization that new terms or ideas needed to be created to communicate the experience.
26:24 Nitrous oxide is both an anxiolytic and an analgesic, meaning it reduces anxiety and pain by triggering certain responses in the brain and activating opioid receptors, and it is also used as a dissociative anesthetic; it can be found in medical settings as well as in products like whipped cream and can be used to increase the oxygen levels in car engines for more horsepower.
31:40 This section of the podcast is not relevant to the topic of nitrous oxide and its effects.
36:55 Nitrous oxide, also known as "hippie crack," became popular in the 70s as a recreational drug at concerts and college dorm rooms due to its short-lived high and quick recovery time.
42:08 Nitrous oxide is expelled from the body through breathing, which is why it is known for its short-lived high and lack of hangover, but it can still cause damage to the brain and lead to brain damage and cell death when used in high concentrations or for prolonged periods of time.
47:14 Nitrous oxide can be deadly, even in medical settings, and can lead to death, comas, brain damage, and accidents.
52:28 Nitrous oxide self-administration allows women to feel more in control of their own comfort during childbirth without any adverse effects.
57:58 This section of the transcript is not relevant to summarizing the podcast episode titled "Selects: How Nitrous Oxide Works" from "Stuff You Should Know" as it consists of thank you messages and advertisements.
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