00:00 This podcast episode discusses a family in Kentucky known as the "blue people" who have a rare condition that causes their skin to appear blue.

05:12 The "blue people" in Kentucky have a rare genetic mutation that causes their skin to appear blue, and this condition was passed down through generations due to inbreeding.

10:24 Metimoglobinemia is a blood disorder that causes the skin to appear blue due to the presence of oxidized iron in the blood.

15:34 Metemoglobinemia is a blood disorder that can cause the skin to turn blue, but it doesn't necessarily affect the oxygen levels in the body.

20:28 Metemoglobinemia is a rare genetic condition where the body is unable to convert excess metemoglobins into hemoglobin, causing the skin to turn blue, but it can be easily treated with a pill.

25:42 Dr. Madison Cawein, a hematologist at the University of Kentucky, went out of his way to find and study these blue people, eventually discovering that the condition was genetic and could be treated with methylene blue.

30:21 The Fugate family started moving away over time, leading to fewer interbreeding and fewer blue babies, and now there is a treatment available for those who don't want to be blue.

35:22 Excess silver ions in the body react to light and form dark deposits on the skin, causing a silverish appearance that is irreversible and cannot be removed, and while there is no evidence of any beneficial effects of taking silver internally, it is still frequently consumed in the form of colloidal silver supplements, which can potentially lead to the development of silver-resistant microbes.

40:18 Silver has antimicrobial properties and was used as an early antibiotic, but its use as a medicine was discontinued due to the risk of turning blue, and it is now sold as a supplement.

45:37 There is no peer-reviewed evidence to support the effectiveness of colloidal silver, and taking it can result in permanent blue skin.

50:23 The hosts receive a listener mail praising their episode on Mr. Na vaccines and their ability to present facts in a relatable way, and they mention that people with Methemoglobinemia can actually blush blue.