Prompt Cast
Peter Attia's Experiment with Fasting and Nutritional Ketosis
TLDR Peter Attia conducted a week-long fast to study autophagy and personalized fasting approaches, tracking various health markers before, during, and after the fast. The experiment showed changes in lipid levels, thyroid function, and other markers, highlighting the potential benefits and impacts of fasting on health.
Timestamped Summary
00:00
The episode discusses Peter's week-long fast sandwiched between two weeks of nutritional ketosis, exploring the rationale behind the experiment and its potential implications.
06:47
Peter's week-long fast aimed to study autophagy and develop a protocol to measure its effects, emphasizing the need for personalized fasting approaches.
13:49
Peter tracks his sleep using an aura ring and has been in a good meditative routine, while also discussing his stress levels and supplements taken, including metformin, with no changes during the fasting period.
20:27
Peter took shirtless photos seven days apart to track muscle mass changes during his fasting period, maintaining his exercise routine and analyzing various lab markers before, during, and after the fast.
27:38
Peter tracked his exercise routines, BHB levels, and supplement intake during his week of nutritional ketosis and fasting, noticing minimal subjective changes in how he felt or performed.
34:32
Peter's thyroid function was impacted during his week of nutritional ketosis and fasting, with changes in T3, reverse T3, and weight loss observed.
41:44
Peter did not have specific targets for macronutrient intake during his week of nutritional ketosis and fasting, but estimated his carb intake at around 30-40 grams per day, protein at 110-120 grams per day, and did not restrict fat intake, feeling less hungry overall.
48:33
Peter's lipid levels changed significantly after a week of fasting, with a drop in total cholesterol, LDL, and HDL, while inflammatory markers improved, uric acid levels spiked, and thyroid function was severely impacted.
55:10
Peter experienced changes in his testosterone, IGF, hematocrit, hemoglobin, weight, ketone levels, and other markers during his week-long fast followed by a refeed on a ketogenic diet.
01:01:55
Peter discusses changes in his blood markers, particularly focusing on his LDL and HDL levels, during his week-long fast followed by a refeed on a ketogenic diet.
01:09:06
Fasting improved Peter's sleep quality, strength during weightlifting, and reduced pain in his wrist and elbow, while also enhancing his meditative routine and mindfulness.
01:15:51
Fasting can potentially enhance awareness and alertness, leading to a heightened sense of cognitive and physical readiness, while also potentially preserving lean tissue mass.
01:22:39
Frequent fasting may potentially lead to lean tissue loss over time, emphasizing the importance of preserving lean mass through activities like weight training to counteract this effect.
01:29:12
Different fasting protocols, including variations in macronutrient composition and calorie intake, can impact enjoyment levels and satisfaction during fasting, but determining the optimal fasting regimen for longevity and health benefits remains uncertain due to limitations in current research methods.
01:35:56
Fasting frequency and protocols may vary based on individual health status, with considerations for metabolic improvements influencing the need for more or fewer fasting-mimicking diets.
01:42:30
Fasting protocols can vary in terms of calorie intake and frequency, with a focus on understanding individual goals and metabolic responses.
Categories:
Health & Fitness
