Prompt Cast
Exploring NAD, Rapamycin, and Metformin as Anti-Aging Interventions
TLDR The podcast discusses NAD, rapamycin, and metformin as potential anti-aging interventions, highlighting challenges in finding biomarkers of aging and the importance of functional improvements in health indicators. Concerns are raised about the commercialization of aging clocks and supplements claiming to reverse biological age.
Timestamped Summary
00:00
The episode focuses on discussing NAD, rapamycin, and metformin as potential anti-aging interventions, exploring their mechanisms and comparing the available data on their effects.
03:40
The podcast delves into the science of aging, focusing on NAD, rapamycin, and metformin as key molecules with potential anti-aging properties.
07:09
The search for biomarkers of aging remains challenging, with ongoing efforts to find predictive measures of biological age at both individual and population levels.
10:35
Blood-based biomarkers and functional biomarkers are valuable tools in predicting and potentially improving lifespan and health span through interventions aimed at modulating underlying aging biology.
14:07
Functional improvements in areas such as VO2 max, muscle mass, cardiovascular efficiency, and metabolic markers are key indicators of progress in patient health, contrasting the focus on epigenetic clocks in aging research.
17:45
Epigenetic clocks may provide insights into future health risks, but their effectiveness in predicting individual health outcomes remains unproven, highlighting the need for definitive lifespan studies in mice to validate their accuracy.
21:08
Epigenetic clocks may offer insights into aging processes, but their ability to predict individual health outcomes remains uncertain, raising questions about their potential utility compared to traditional phenotypic tests linked to longevity.
24:36
The commercialization of aging clocks and pairing them with supplements raises concerns about the accuracy and ethics of measuring biological age and selling products claiming to reverse it, potentially misleading the public.
27:56
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Categories:
Health & Fitness
