Prompt Cast
Dominic D'Agostino on Optimizing Health and Performance with Ketosis
TLDR Dominic D'Agostino discusses his research on the effects of hyperbaric oxygen on cancer cells, the potential benefits of ketones in slowing cancer cell growth, and the use of ketone esters in hyperbaric chambers to increase resistance to oxygen toxicity. His work highlights the role of ketones in shifting brain energy metabolism, potential applications of hyperbaric oxygen therapy, and the ketogenic diet's impact on cancer cell growth and proliferation.
Timestamped Summary
00:00
The podcast episode features an interview with Dominic D'Agostino, a professor known for his expertise in ketosis and exogenous ketones, focusing on technical discussions and insights on optimizing health and performance.
07:36
Dominic D'Agostino discusses his research on the effects of hyperbaric oxygen on cancer cells, observing increased superoxide production and accelerated membrane lipid peroxidation leading to cell death.
15:56
Dominic D'Agostino researched the effects of hyperbaric oxygen on seizures and discovered that cancer cells use reactive oxygen species for growth and proliferation, with ketones showing potential to slow cancer cell growth.
24:16
Healthy neurons thrive in a low glucose environment with ketones present, while cancer cells die, leading to Dominic D'Agostino's interest in studying cancer and the Warburg effect.
32:24
The research delves into the reasons behind seizures in Navy SEAL divers and the potential benefits of using ketone esters in hyperbaric chambers to increase resistance to oxygen toxicity.
40:47
The FDA has approved hyperbaric oxygen therapy for various applications including radiation necrosis, decompression sickness, diabetic wounds, and noise-induced hearing loss, with potential controversial applications for traumatic brain injury.
48:54
Subjects fasted for 40 days, consuming only water and minerals, with well-documented monitoring of various metabolites, showing a shift in brain energy metabolism towards ketones as the primary fuel source.
57:06
Remarkable observations in animals led to a shift in understanding metabolic physiology and brain energy metabolism towards fats and ketones as primary fuel sources, with lactate also being recognized as a potential fuel for the brain.
01:05:41
The complexity of the Krebs cycle, especially in relation to cancer cells, is being reevaluated, with new research highlighting the role of aspartate and glutamine in cancer metabolism.
01:13:49
Dom D'Agostino experimented with gradually increasing his intake of MCTs to improve tolerability, spreading them out over multiple meals to avoid gastrointestinal issues, and highlighted the potential anti-seizure properties of MCTs independent of ketones.
01:21:58
The discussion explores the potential mechanisms behind exogenous ketone-induced release of insulin and its impact on glucose disposal and insulin sensitivity over time.
01:30:14
Being in the water and experiencing hypothermia led to significant changes in ketone levels and glucose, resembling a prolonged fast.
01:38:22
Research in 1975 identified beta hydroxybutyrate as a potential space fuel, leading to the development of exogenous ketones like sodium beta hydroxybutyrate and ketone salts and esters with different properties.
01:46:51
A potent diester of acetoacetate, combined with 1,3 butane diol, elevates beta hydroxybutyrate and acetoacetate in a 1:1 ratio, showing positive biomarker effects but with an unpleasant taste, potentially more suited for medical food use.
01:55:23
Consuming high levels of ketones can lead to feeling weird, and athletes may dispose of ketones more effectively due to upregulated metabolic machinery, with fat-adapted athletes being good ketone utilizers.
02:03:32
The ketogenic diet targets cancer cell growth and proliferation by achieving a glucose ketone index of one to two, which can be maintained through a supplemented ketogenic intermittent fasting approach.
02:12:18
Hyperbaric oxygen therapy can reverse tumor hypoxia by increasing tissue oxygenation, driving oxygen into the plasma to target cancer cells.
02:20:49
Research is being conducted on the use of various therapies, including hyperbaric oxygen, IV vitamin C, and cancer-specific glycolytic inhibitors, to create a comprehensive metabolic-based therapy for cancer treatment.
02:29:38
Experimenting on extreme physiologic conditions, such as a seven-day fast, revealed the resilience and benefits of being in a keto-adapted state, leading to insights on ketones as powerful endogenous metabolites with epigenetic control over gene transcription.
02:38:38
The Metabolic Health Summit offers a range of information from basic science to clinical applications, with opportunities for sponsorship and high-profile representation, making it a valuable resource for those interested in metabolic health.
Categories:
Health & Fitness
