Prompt Cast
Dom D'Agostino on Ketogenic Diets and Metabolic Flexibility
TLDR Dom D'Agostino discusses the benefits of intermittent ketosis, the use of various devices to measure ketones and glucose levels, and the impact of exogenous ketones on endogenous ketone production and therapeutic applications.
Timestamped Summary
00:00
Dom D'Agostino participates in a two-part Ask Me Anything series covering ketogenic diets, ketosis, and the impact on different forms of exercise.
03:30
Dom D'Agostino has been focusing on moving laboratory science into human applications, conducting research on the effects of ketosis in extreme environments like NASA missions and developing ketone metabolic therapies for diseases such as cancer and genetic disorders.
07:01
Intermittent ketosis can promote metabolic flexibility and activate a genetic program that allows the body to efficiently burn fat and make ketones, leading to benefits such as metabolic memory and personal development.
10:39
To experience some benefits of ketosis without completely eliminating carbs, consider trying a restricted ketogenic diet for five to seven days once a month, aiming for a glucose ketone index of one to two for potential benefits like insulin suppression.
14:00
Various devices such as urine strips, blood meters like the Precision Extra and Keto Mojo, and breath acetone meters like Biosense can be used to measure ketones and glucose levels for those following a ketogenic diet.
17:46
Different colors on the Biosense breath acetone meter indicate different levels of ketosis, with higher numbers correlating to higher beta hydroxybutyrate levels, making it a reliable and quantitative device for measuring ketosis.
21:14
Acetone levels in the breath can indicate the utilization of ketones, with exercise impacting acetone levels and athletes showing quick clearance of exogenous ketones during a ketone tolerance test.
24:27
Exogenous ketones may impact endogenous ketone production and have therapeutic applications, with genes like EG and FTO possibly influencing how individuals handle saturated fats in their diet.
Categories:
Health & Fitness
