Prompt Cast
Cellular Reprogramming and NAD: Key Insights for Anti-Aging Strategies
TLDR Cellular reprogramming through DNA methylation patterns and NAD boosters like NR show promising potential in reversing aging and restoring youthful gene expression levels, with implications for longevity and age-related diseases. Research on gene therapy and cellular reprogramming is advancing rapidly, but challenges remain in terms of cost, production, and optimizing interventions like fasting for anti-aging benefits.
Timestamped Summary
00:00
The podcast host explains why the podcast relies on listener support instead of running ads and introduces the guest, Professor David Sinclair, to discuss cellular reprogramming and the latest research on NAD.
07:11
The book discusses the importance of the Sertuan genes in controlling aging and maintaining cellular identity through the analogy of first responders in a disaster scenario.
14:31
Cells have DNA that can be turned on or off through epigenetic modifications like methylation, which play a crucial role in maintaining cellular identity and preventing cells from losing their specific functions as they age.
21:39
Cells can be reprogrammed to reverse aging by restoring DNA methylation patterns to their youthful state.
28:35
Cells age as telomeres erode, but recent research has identified a clock based on DNA methylation patterns that can accurately determine an individual's age.
35:27
Cells can be reprogrammed to restore their youthful gene expression patterns and function, potentially reversing the aging process.
42:32
Cells were reprogrammed to be partially young again without the need for the oncogene gene MIC, using a doxycycline-responsive gene system in mice, resulting in nerve regeneration and restored vision in glaucoma and old mice.
49:27
Cells reprogrammed to reverse aging show a remarkable ability to restore gene expression levels to a more youthful state, potentially through epigenetic mechanisms that remain to be fully understood.
56:45
Research on gene therapy and cellular reprogramming is progressing rapidly, with promising clinical trials underway for diseases like sickle cell anemia, but challenges remain in terms of cost and production.
01:03:50
Research is needed to determine the optimal frequency and dosage of interventions like fasting, as current biomarkers are insufficient to provide accurate insights into their effects on aging.
01:11:09
Senescent cells in the body can be identified by specific genes and characteristics, but there is currently no definitive way to reverse senescence, making it a challenging process to address in aging.
01:18:08
Advancements in adenovirus technology may allow for the selection of specific tissues for reprogramming, potentially leading to organ-specific approaches to aging and longevity.
01:25:24
Advancements in technology have led to a global increase in maximum lifespan, but lifestyle factors like diet, exercise, stress, and sleep may be limiting further gains in longevity.
01:32:18
Timing and personal considerations influence the use of metformin, rapamycin, and resveratrol in relation to diet, exercise, and fasting for potential longevity benefits.
01:39:01
Resveratrol extends lifespan by activating Sirtuin 1, and NAD is crucial for cellular function and signaling in the body.
01:46:16
NR, or nicotinamide riboside, is a precursor to NAD that is more effective at raising NAD levels in the body compared to high doses of vitamin B3, with studies showing its potential benefits in increasing NAD levels in muscle and avoiding the inhibitory effects of nicotinamide on sirtuins.
01:53:38
The absorption of NR in the body can be influenced by factors such as swallowing versus sublingual administration, the role of the microbiome in breaking down molecules, and the complex process of how NR is metabolized and utilized in the body.
02:00:48
Research suggests that NAD boosters like NR and terastilbine may have more significant benefits for individuals with health conditions affecting NAD levels, such as ALS, compared to those who are already in peak condition.
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Health & Fitness
